During pregnancy, estriol is synthesized in the placenta from ______ formed in the ______.

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Study for the Ciulla Clinical Chemistry Test. Enhance your knowledge with flashcards and multiple-choice questions. Prepare for the exam with comprehensive study materials and detailed explanations for each question.

Multiple Choice

During pregnancy, estriol is synthesized in the placenta from ______ formed in the ______.

Explanation:
During pregnancy the placenta builds estrogens from precursors supplied by the fetus. Estriol, the dominant estrogen in late gestation, is synthesized in the placenta from 16α-hydroxy-DHEA-S, which is formed in the fetus (primarily by the fetal liver/adrenal). The fetal precursor is transported to the placenta, where placental enzymes convert it into estriol. This is why the correct statement is that 16α-hydroxy-DHEA-S is formed in the fetus and then used by the placenta to make estriol.

During pregnancy the placenta builds estrogens from precursors supplied by the fetus. Estriol, the dominant estrogen in late gestation, is synthesized in the placenta from 16α-hydroxy-DHEA-S, which is formed in the fetus (primarily by the fetal liver/adrenal). The fetal precursor is transported to the placenta, where placental enzymes convert it into estriol. This is why the correct statement is that 16α-hydroxy-DHEA-S is formed in the fetus and then used by the placenta to make estriol.

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