In Graves disease, which two laboratory values are elevated relative to normal?

In Graves disease, which two laboratory values are elevated relative to normal?

• A. Free T4 and TSH
• B. Free T4 and THBR
• C. THBR and TSH
• D. Free T3 and THBR

Answer: (B)

In Graves disease, the thyroid gland is overactive, so circulating thyroid hormones rise while TSH is suppressed by negative feedback. The two values that reflect this hyperthyroid state in the given context are the free T4 level, which is elevated because more hormone is produced and released, and the thyroid hormone-binding ratio (THBR), which also increases due to the altered binding dynamics when hormone levels are high. The other patterns don’t fit Graves: TSH is typically low, not elevated, and while free T3 can be elevated, the choice that pairs free T4 with THBR best matches the classic hyperthyroid profile used in this assessment.

In Graves disease, the thyroid gland is overactive, so circulating thyroid hormones rise while TSH is suppressed by negative feedback. The two values that reflect this hyperthyroid state in the given context are the free T4 level, which is elevated because more hormone is produced and released, and the thyroid hormone-binding ratio (THBR), which also increases due to the altered binding dynamics when hormone levels are high. The other patterns don’t fit Graves: TSH is typically low, not elevated, and while free T3 can be elevated, the choice that pairs free T4 with THBR best matches the classic hyperthyroid profile used in this assessment.