Lactate dehydrogenase requires which cofactor for its catalytic action?

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Study for the Ciulla Clinical Chemistry Test. Enhance your knowledge with flashcards and multiple-choice questions. Prepare for the exam with comprehensive study materials and detailed explanations for each question.

Multiple Choice

Lactate dehydrogenase requires which cofactor for its catalytic action?

Explanation:
Lactate dehydrogenase uses NAD+/NADH as its electron carrier. In the reaction where lactate is oxidized to pyruvate, NAD+ accepts a hydride to become NADH. In the reverse direction, NADH donates a hydride to pyruvate to form lactate. This NAD+/NADH system is the specific cofactor for LDH, whereas NADP+ is used by different enzymes in other pathways, and flavin cofactors like FAD or FMN are involved in other dehydrogenases. So, the cofactor required for LDH’s catalytic action is NAD+.

Lactate dehydrogenase uses NAD+/NADH as its electron carrier. In the reaction where lactate is oxidized to pyruvate, NAD+ accepts a hydride to become NADH. In the reverse direction, NADH donates a hydride to pyruvate to form lactate. This NAD+/NADH system is the specific cofactor for LDH, whereas NADP+ is used by different enzymes in other pathways, and flavin cofactors like FAD or FMN are involved in other dehydrogenases. So, the cofactor required for LDH’s catalytic action is NAD+.

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