NAPA is the active metabolite of which antiarrhythmic drug?

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Study for the Ciulla Clinical Chemistry Test. Enhance your knowledge with flashcards and multiple-choice questions. Prepare for the exam with comprehensive study materials and detailed explanations for each question.

Multiple Choice

NAPA is the active metabolite of which antiarrhythmic drug?

Explanation:
NAPA stands for N-acetylprocainamide, formed when procainamide is metabolized in the liver by acetylation. It stays pharmacologically active as a sodium-channel blocker and often has a longer half-life, contributing to the overall antiarrhythmic effect beyond the parent drug. So, the antiarrhythmic drug whose active metabolite is NAPA is procainamide. (Pronestyl is the brand name for procainamide, so it’s the same drug; disopyramide does not produce NAPA.)

NAPA stands for N-acetylprocainamide, formed when procainamide is metabolized in the liver by acetylation. It stays pharmacologically active as a sodium-channel blocker and often has a longer half-life, contributing to the overall antiarrhythmic effect beyond the parent drug. So, the antiarrhythmic drug whose active metabolite is NAPA is procainamide. (Pronestyl is the brand name for procainamide, so it’s the same drug; disopyramide does not produce NAPA.)

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