Nortriptyline is the active metabolite of which of the following drugs?

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Study for the Ciulla Clinical Chemistry Test. Enhance your knowledge with flashcards and multiple-choice questions. Prepare for the exam with comprehensive study materials and detailed explanations for each question.

Multiple Choice

Nortriptyline is the active metabolite of which of the following drugs?

Explanation:
Nortriptyline is produced when amitriptyline is demethylated in the liver, turning the tertiary amine into a secondary amine metabolite that still has antidepressant activity. That’s why amitriptyline is the drug whose active metabolite is nortriptyline. Other TCAs have different active metabolites: imipramine is demethylated to desipramine, and doxepin is converted to nordoxepin, so those metabolites are not nortriptyline.

Nortriptyline is produced when amitriptyline is demethylated in the liver, turning the tertiary amine into a secondary amine metabolite that still has antidepressant activity. That’s why amitriptyline is the drug whose active metabolite is nortriptyline. Other TCAs have different active metabolites: imipramine is demethylated to desipramine, and doxepin is converted to nordoxepin, so those metabolites are not nortriptyline.

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