Which disorder is not a form of hepatic jaundice?

Which disorder is not a form of hepatic jaundice?

• A. Cirrhosis
• B. Crigler-Najjar syndrome
• C. Hepatitis
• D. Neoplasm of common bile duct

Answer: (D)

Jaundice types hinge on where bilirubin processing fails: hepatic jaundice arises from liver cell injury or impaired conjugation, while posthepatic (obstructive) jaundice comes from a blockage of bile flow after the liver. Cirrhosis and hepatitis directly damage hepatocytes, causing impaired processing and mixed bilirubin elevation characteristic of hepatic jaundice. Crigler-Najjar is a congenital defect in bilirubin conjugation within the liver, so it also fits under hepatic jaundice. If bile flow is obstructed, such as by a neoplasm blocking the common bile duct, bilirubin (especially the conjugated form) backs up into the blood, producing posthepatic jaundice. Therefore, a blockage in the common bile duct is not hepatic jaundice.

Jaundice types hinge on where bilirubin processing fails: hepatic jaundice arises from liver cell injury or impaired conjugation, while posthepatic (obstructive) jaundice comes from a blockage of bile flow after the liver. Cirrhosis and hepatitis directly damage hepatocytes, causing impaired processing and mixed bilirubin elevation characteristic of hepatic jaundice. Crigler-Najjar is a congenital defect in bilirubin conjugation within the liver, so it also fits under hepatic jaundice. If bile flow is obstructed, such as by a neoplasm blocking the common bile duct, bilirubin (especially the conjugated form) backs up into the blood, producing posthepatic jaundice. Therefore, a blockage in the common bile duct is not hepatic jaundice.